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CCJC学友讲座通知(2011年10月25日发布)

JIC学友讲座:

时间:2011年10月27日上午9:00

地点:中国农业科学院作物科学研究所(重大工程楼二楼)报告厅

主持人:毛龙 博士

报告人:刘焕庭 博士

报告题目:Structural Proteomics of Rational Targets at Scottish Structural Proteomics Facility (SSPF)

报告人简介:

刘焕庭博士,苏格兰结构蛋白组学研究中心项目经理,高级研究员。现任职于英国圣. 安德鲁斯大学生物医学科学研究综合体苏格兰结构蛋白组学研究中心(Scottish Structural Proteomics Facility, Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK). 兼职山东农业大学讲座教授, 青岛农业大学客座教授, 英国华威大学(Warwick University)博士学位答辩专家,《抗感染药物研发新专利杂志》, (Recent Patents on Anti-Infective Drug Discovery)编辑咨询委员会委员,《核酸》, 《病毒学杂志》及《Current Topics in Microbiology and Immunology》 等多种杂志特约审稿人.

 

Selected Recent Publications 

Oke M, Carter LG, Johnson KA, Liu H, McMahon SA, Yan X, Kerou M, Weikart ND, Kadi N, Sheikh MA, Schmelz S, Dorward M, Zawadzki M, Cozens C, Falconer H, Powers H, Overton IM, van Niekerk CA, Peng X, Patel P, Garrett RA, Prangishvili D, Botting CH, Coote PJ, Dryden DT, Barton GJ, Schwarz-Linek U, Challis GL, Taylor GL, White MF, Naismith JH. (2010).  The Scottish Structural Proteomics Facility: target, methods and outputs. Journal Of Structural Functional Genomics  2010 Apr 24 [Epub ahead of print]

McMahon SA, Roberts GA, Johnson KA, Cooper LP, Liu H, White JH, Carter LG,Sanghvi B, Oke M, Walkinshaw MD, Blakely GW, Naismith JH and Dryden DT. (2009). Extensive DNA mimicry by the ArdA anti-restriction protein and its role in the spread of antibiotic resistance. Nucleic Acids Res. 37:4887-97.

McRobbie AM, Carter LG, Kerou M, Liu H, McMahon SA, Johnson KA, Naismith JH and White MF. (2009). Structural and Functional Charaterisation of a Conserved Archaeal RadA Paralog with Antirecombinase Activity. Journal of Molecular Biology 389(4):661-73.

Schmelz S, Kadi N, McMahon SA, Song L, Oves-Costales D, Oke M, Liu H, Johnson KA, Carter LG, Botting CH, White MF, Challis GL and Naismith JH. (2009). AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis. Nature Chemical Biology 5(3):174-182.

Liu H and Naismith J H. (2009). A simple and efficient expression and purification system using two newly constructed vectors. Protein Expression and Purification 63:102-111.

Liu H and Naismith J H. (2008). An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol. BMC Biotechnology 8:91 

McMahon SA, Oke M, Liu H, Johnson KA, Carter LG, Kadi N, White MF, Challis GL and Naismith JH. (2008). Purification, crystallization and data collection of Pectobacterium chrysanthemi AcsD, a type A siderophore synthetase. Acta Cryst.  F  64(Pt 11):1052-1055.

Oke M, Ching RT, Carter LG, Johnson KA, Liu H, McMahon SA, White MF, Bloch C Jr. Botting C H, Walsh M A, Latiff AA, Kennedy MW, Cooper A and Naismith J H. (2008). Unusual Chromophore and Cross-Links in Ranasmurfin: A Blue Protein from the Foam Nests of a Tropical Frog. Angew Chem Int Ed Engl. 47(41):7853-7856.

Liu H, Rudolf J, Johnson KA, McRobbie A-M, McMahon SA, Oke M, Carter LG, Brown SE, Naismith JH and White MF. (2008). Structure of the DNA repair helicase XPD. Cell 133(5):801-812.

Fairhead M, Johnson KA, Kowatz T, McMahon SA, Carter LG, Oke M., Liu H, Naismith JH and van der Walle CF. (2008). Crystal structure and silica condensing activities of silicatein a/cathepsin L chimeras. Chemical Communications (Camb) 21(15):1765-1767.

Richards JD., Cubeddu L, Roberts J, Liu H and White MF. (2008). The archaeal XPB protein is an ssDNA-dependent ATPase with a novel partner. Journal of Molecular Biology 376(3):634-644.

Richards JD, Johnson KA, Liu H, McRobbie A-M, McMahon SA, Oke M, Carter LG, Naismith JH and White MF. (2008). Structure of the DNA repair helicase HEL308 reveals DNA binding and autoinhibitory domains. Journal of Biological Chemistry 283(8): 5118-5126.

Liu H. (2008). Viral Protein-Nucleic Acid Interaction: South(North)-Western Blot. Methods in Molecular Biology 451:405-420.

Liu H, Woznica K, Catton G, Crawford A, Botting,N and Naismith JH. (2007). Structural and kinetic characterization of quinolinate phosphoribosyltransferase (HQPRTase) from Homo sapiens. Journal of Molecular Biology 373(3): 755-763.

Seetharamappa J, Oke M, Liu H, McMahon SA, Johnson KA, Carter LG, Dorward M, Zawadzki M, Overton IM, van Niekirk CAJ, Graham S, Botting CH, Taylor GL, White MF, Barton GJ, Coote PJ and Naismith JH. (2007). Purification, crystallization and data collection of methicillin-resistant Staphylococcus aureus Sar2676, a pantothenate synthetase. Acta Cryst. F 63:488-491.

Yard BA, Carter LG, Johnson KA, Overton IM, Dorward M, Liu H, McMahon SA, Oke M, Puech D, Barton GJ, Naismith JH and Campopiano DJ. (2007). The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis. Journal of Molecular Biology 370(5):780-886.

Seetharamappa J, Oke M, Liu H, McMahon SA, Johnson KA, Carter LG, Dorward M, Zawadzki M, Overton IM, van Niekirk CAJ, Graham S, Botting CH, Taylor GL, White MF, Barton GJ, Coote PJ and Naismith JH. (2007). Expression, purification, crystallization, data collection and preliminary biochemical characterization of methicillin-resistant Staphylococcus aureus Sar2028, an aspartate/tyrosine/phenylalanine pyridoxal-5'-phosphate-dependent aminotransferase. Acta Cryst. F 63:452-456.

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